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The Functional Breeding Podcast is about how to breed dogs for function and for health, behavioral and physical. It is brought to you by the Functional Dog Collaborative, a non-profit organization founded to support the ethical breeding of healthy, behaviorally sound dogs. The FDC’s goals include providing educational, social, and technical resources to breeders of both purebred and mixed breed dogs, helping us all learn more about how to breed good companions who are fit for sports or work. You can find out more at functionalbreeding.org or at the Functional Breeding facebook group, which is a friendly and inclusive community.
Episodes
Tuesday Nov 26, 2024
Genetic Testing Cavaliers for Heart Disease
Tuesday Nov 26, 2024
Tuesday Nov 26, 2024
This episode is just me (Jessica Perry Hekman, DVM, PhD) - talking about a new genetic test for the risk of mitral valve disease in Cavalier King Charles Spaniels. Cavs are at incredibly high risk of this disease and get it at much younger ages than other breeds. What does this new test mean in terms of predicting if your Cav is at risk, and whether a particular Cav should be bred?
I talk about several papers in this episode. If you want to check them out yourself, they are:
- Mead, Sophie E., et al. "Genetic Variants at the Nebulette Locus Are Associated with Myxomatous Mitral Valve Disease Severity in Cavalier King Charles Spaniels." Genes 13.12 (2022): 2292. - https://pmc.ncbi.nlm.nih.gov/articles/PMC9778376/
- Mattin, M. J., et al. "Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary‐care veterinary practices in England." Journal of Veterinary Internal Medicine 29.3 (2015): 847-854. - https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.12591
- Keene, Bruce W., et al. "ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs." Journal of veterinary internal medicine 33.3 (2019): 1127-1140. - https://pmc.ncbi.nlm.nih.gov/articles/PMC6524084/
Thursday Nov 14, 2024
Kim Kavin: The Dog Merchants
Thursday Nov 14, 2024
Thursday Nov 14, 2024
Kim Kavin is an award-winning freelance writer who is also passionate about better understanding where dogs come from in the United States. Her book, The Dog Merchants, is a fascinating read for anyone who wants a look at places few of us are able to go, such as a dog auction or a high volume kennel-based breeding operation. Kim and I talked about the ins and outs of the complex industry that has grown up around puppy production, including large scale breeding and rescue operations.
In this interview, the two of us are describing a system that is absolutely sub-optimal with regard to canine welfare. While we did discuss how some parts of the system may not be as abhorrent as they've been described elsewhere, I want to be clear that one of the goals of the Functional Dog Collaborative is to make change in exactly this area. So please do not confuse our descriptions of what is existing for our approval of it.
You can find Kim at kimkavin.com. In addition to her book The Dog Merchants, you may also enjoy checking out her book Little Boy Blue (also discussed briefly in this interview).
Monday Oct 28, 2024
Daniel Mills, BVSc, ECAWBM(BM), PhD: Pain and behavior problems
Monday Oct 28, 2024
Monday Oct 28, 2024
This week I'm talking to Daniel Mills, Professor of Veterinary Behavioural Medicine at the University of Lincoln and director of the University Animal Behaviour Clinic. Daniel is internationally recognized as an authority on companion animal behavior, cognition, and welfare. His lab studies, among other things, the association between untreated pain and behavior issues. I asked him to talk about his research and his insights into the challenges of assessing pain in dogs - and why it's so important to do so.
Thursday Oct 17, 2024
Dr. Cat Henstridge: Unlicensed fertility clinics in the UK
Thursday Oct 17, 2024
Thursday Oct 17, 2024
This week I'm talking with Dr. Cat Henstridge. Cat, who is a primary care veterinarian in the UK, has been on several TV series, including the Pets Factor. She writes for veterinary and non-veterinary publications, and is known as Cat the Vet to her many, many social media followers. Cat and I talked about the rise of unlicensed fertility clinics in the UK - why they have sprung up, what the problems with them are, and some thoughts about how many veterinarians interact with breeder clients.
You can follow Cat at catthevet.com, on Instagram and TikTok as cat_the_vet, and on Facebook as catthevet.
Monday Sep 30, 2024
Monday Sep 30, 2024
This week I'm talking to Dr Jane Ladlow. Jane is a veterinary surgeon who is widely known as an expert on BOAS, or brachycephalic obstructive airway syndrome. BOAS is the umbrella disorder that covers a variety of different airflow obstructions in different flat-faced breeds such as the pug, French bulldog, and English bulldog. Jane developed the Respiratory Function Grading Scheme, a straightforward clinical exam which allows grading of a BOAS-effected dog. Jane works with the Kennel Club in the UK to promote this scheme, which is also being rolled out in other countries including the US. I was really pleased to get to talk to Jane about BOAS, her grading scheme, and what this means for breeding healthy brachycephalic dogs.
Monday Sep 16, 2024
Gina Bryson and Drs O'Neill and Packer: The Doodle Dilemma
Monday Sep 16, 2024
Monday Sep 16, 2024
Today I'm talking with the researchers who recently published a paper that's been getting a lot of social media buzz. The paper's title is "The doodle dilemma: How the physical health of ‘Designer-crossbreed’ Cockapoo, Labradoodle and Cavapoo dogs’ compares to their purebred progenitor breeds." This interview was a big party featuring Gina Bryson, the first author on the paper, as well as two researchers from Royal Veterinary College, Dr Rowena Packer, and Dr Dan O'Neill, who has been a guest on the podcast before. Gina, Rowena, and Dan walked me through what the paper does and does not tell us about the health of some specific common crosses compared to the parent breeds, and also let me know about additional data that they collected that we'll be seeing in some future papers from the group.
A quick side note that they refer a few times to the RVC, which is the Royal Veterinary College, the institution where they work.
And another side note - I've started going by my middle name, Perry, because I like it better. My pronouns are still she/her. You'll hear Dan call me Perry a few times during this episode and I didn't want anyone to be confused by that. Jessica is still my legal and professional name - if it helps to contextualize, you can think of Perry as a nickname.
On with the episode!
Bryson GT, O’Neill DG, Brand CL, Belshaw Z, Packer RMA (2024) The doodle dilemma: How the physical health of ‘Designer-crossbreed’ Cockapoo, Labradoodle and Cavapoo dogs’ compares to their purebred progenitor breeds. PLoS ONE 19(8): e0306350. https://doi.org/10.1371/journal.pone.0306350
Monday Sep 09, 2024
What is the coefficient of inbreeding (COI) and why does it matter?
Monday Sep 09, 2024
Monday Sep 09, 2024
This week you get just me (Jessica Perry Hekman) talking at you! I'm talking about the coefficient of inbreeding (COI), a measurement of genetic diversity that's commonly mentioned in discussions of individual and breed health. I talk about what it is, how to interpret it, how to get the measurement done for your own dog(s), why we care about it, and give the take-home messages from some papers with evidence for its importance in dog specifically. COI is not the only thing you should be breeding for, and it's rarely even the most important thing - but it's something we should keep in mind when we are working in closed gene pools.
NOTE: Oops, I said in the episode that the MDR1 mutation is recessive. It's not - it's incompletely dominant, meaning that dogs can be affected even with only one copy of the mutant allele. I apologize - please note the mistake as the correct information is important here.
- I mention some previous podcast episodes with related material - you can find them here:
Alison Skipper, PhD on the history of breed registries: https://functionalbreeding.podbean.com/e/alison-skipper-phd-the-history-of-breed-registries/ - Mary Peaslee, MD, MPH, on breeding for population health: https://functionalbreeding.org/breeding-for-population-health/
The papers:
- https://functionalbreeding.org/the-impact-of-inbreeding-on-litter-size/ - Chu ET, Simpson MJ, Diehl K, Page RL, Sams AJ, Boyko AR. Inbreeding depression causes reduced fecundity in Golden Retrievers. Mammalian Genome. 2019 Jun 1;30(5):166-72. - "The least inbred dogs had an average litter size of 8 puppies, while the most inbred dogs had an average litter size of 6-7 puppies. On average, with each 10% increase in inbreeding, the litter size decreased by one puppy."
- https://functionalbreeding.org/inbreeding-depression-and-lifespan/ - Yordy J, Kraus C, Hayward JJ, White ME, Shannon LM, Creevy KE, Promislow DEL, Boyko AR. Body size, inbreeding, and lifespan in domestic dogs. Conserv Genet. 2020 Feb;21(1):137-148. - mixed breed live on average 1.2 years longer than size matched purebreds
- https://www.sciencedirect.com/science/article/abs/pii/S1090023313004486 - O'Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Longevity and mortality of owned dogs in England. Vet J. 2013 Dec;198(3):638-43. doi: 10.1016/j.tvjl.2013.09.020 - again, mixed breed live on average 1.2 years longer than size matched purebreds
- https://link.springer.com/article/10.1186/s40575-020-00086-8 - Urfer SR, Kaeberlein M, Promislow DEL, Creevy KE. Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States. Canine Med Genet. 2020 Jun 16;7:7. - breeds with lower COI have 3-6 month longer expected lifespans
- https://functionalbreeding.org/size-genetic-diversity-lifespan/ - Kraus C, Snyder-Mackler N, Promislow DEL. How size and genetic diversity shape lifespan across breeds of purebred dogs. Geroscience. 2023 Apr;45(2):627-643. - + 1% heterozygosity -> + 31 days of life
- https://functionalbreeding.org/the-effect-of-inbreeding-body-size-and-morphology-on-health-in-dog-breeds/ - Bannasch, D., Famula, T., Donner, J. et al. The effect of inbreeding, body size and morphology on health in dog breeds. Canine Genet Epidemiol 8, 12 (2021). - 30kg dog: 0->40% COI -> 10% increase in veterinary care visits; 5kg or 60kg: 37% increase
- https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 - Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. - purebred more likely to be affected, mutts to be just carriers
Tuesday Aug 27, 2024
REPLAY: Jane Lindquist: Puppy Culture
Tuesday Aug 27, 2024
Tuesday Aug 27, 2024
I will have new content for you all soon - but for now, enjoy one from the archives!
--
Jane Lindquist is the founder and owner of Puppy Culture, a widely used educational resource for raising and socializing puppies. She herself breeds and competes with bull terriers. As it turns out, she is very thoughtful when it comes to how to apply science to the raising of puppies. We had a wide ranging conversation, at times nerdy, at times philosophical. You can learn more about Puppy Culture at www.puppyculture.com, and more about Jane's breeding program, Madcap Bull Terriers, at www.madcapbullterriers.com.
Find this episode's transcript at functionalbreeding.org/jane-lindquist-puppy-culture/
Thursday Jul 18, 2024
Mary Peaslee, MD, MPH: Breeding for Population Health
Thursday Jul 18, 2024
Thursday Jul 18, 2024
This episode I welcome back Mary Peaslee, MD, MPH, to talk about a breeder's perspective on all the advice Dr Dan O'Neill gave us in his recent episode on how to approach disorder testing. Mary works in population health and brings that perspective to her breeding practice. So what does all this stuff look like in the real world? How can breeders focus on the future health of the dog population they work with? What are some challenges they'll encounter? Mary has some great advice and perspective that I hope will help people think through their breeding goals and approaches.
You can learn more about Mary's breeding program here: https://englishshepherds.net and you can find her on Facebook at https://www.facebook.com/mary.peaslee.9
Detailed summary: https://functionalbreeding.org/breeding-for-population-health/
Tuesday Jul 02, 2024
Tuesday Jul 02, 2024
We have a flipped episode this week with Sarah Stremming of Cog Dog Radio interviewing me. We're talking about the new paper out of the Dog Aging Project, "Lifetime Prevalence of Owner-Reported Medical Conditions in the 25 Most Common Dog Breeds in the Dog Aging Project Pack." There's been a lot of buzz on social media about this paper and we wanted to dig in to its findings. For those who saw our live Q&A about the paper, this interview covers very similar ground, although we go into some more detail. I'll include links to this study and others below, and if you want to ask questions about the paper, the Functional Breeding Facebook group is a great place to do it!
Forsyth, Kiersten K, et al. “Lifetime Prevalence of Owner-Reported Medical Conditions in the 25 Most Common Dog Breeds in the Dog Aging Project Pack.” Frontiers in Veterinary Science, vol. 10, 3 Nov. 2023.
- Original: https://doi.org/10.3389/fvets.2023.1140417
- FDC summary: https://functionalbreeding.org/common-conditions-seen-in-primary-care-visits/
Do purebreds live longer?
- Yordy, J, et al. “Body size, inbreeding, and lifespan in domestic dogs”. Conserv. Genet. 21 (2020): 137-148. - https://functionalbreeding.org/inbreeding-depression-and-lifespan/ - “For a given body size category, mixed breed dogs lived on average 1.2 years longer than purebred ones.”
- Urfer, Silvan R., et al. "Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States." Canine medicine and genetics 7 (2020): 1-14. - https://link.springer.com/article/10.1186/s40575-020-00086-8 - DAP authors before DAP started - “We did not find significant differences in lifespan between purebred and mixed breed dogs; however, breeds with larger effective population sizes and/or lower inbreeding coefficients had median survival times 3–6 months longer than breeds with smaller effective population sizes or higher inbreeding coefficients”
- Mata, Fernando, and Andreia Mata. "Investigating the relationship between inbreeding and life expectancy in dogs: mongrels live longer than pure breeds." PeerJ 11 (2023): e15718. - https://peerj.com/articles/15718/?f...gzQO4ualQE4De4iuO6RmqokNKNTRYdxORkaYEMBwDx_0I - VetCompass data - “mongrel dogs had the highest life expectancy, followed by cross-bred dogs with only one purebred ancestor and purebred dogs had the lowest life expectancy”
Increased inbreeding correlates to decreased lifespan
- Kraus C, et al. “How size and genetic diversity shape lifespan across breeds of purebred dogs”. GeroScience (2022). - https://functionalbreeding.org/size-genetic-diversity-lifespan/
- Bannasch, D., Famula, T., Donner, J. et al. The effect of inbreeding, body size and morphology on health in dog breeds. Canine Genet Epidemiol 8, 12 (2021). - https://functionalbreeding.org/the-effect-of-inbreeding-body-size-and-morphology-on-health-in-dog-breeds/
Are there specific disorders of concern that are more common in purebreds?
- Bellumori, Thomas P., et al. "Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995–2010)." Journal of the American Veterinary Medical Association 242.11 (2013): 1549-1555. - https://avmajournals.avma.org/view/journals/javma/242/11/javma.242.11.1549.xml - UC Davis, 24 heritable (genetic) disorders - “Purebred dogs were more likely to have 10 genetic disorders, including dilated cardiomyopathy, elbow dysplasia, cataracts, and hypothyroidism. Mixed-breed dogs had a greater probability of ruptured cranial cruciate ligament.”
- Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 - “Mixed breed dogs were more likely to carry a common recessive disease, whereas purebreds were more likely to be genetically affected with one, providing DNA-based evidence for hybrid vigor.” (i.e. it isn’t a problem if you don’t inbreed on it)