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The Functional Breeding Podcast is about how to breed dogs for function and for health, behavioral and physical. It is brought to you by the Functional Dog Collaborative, a non-profit organization founded to support the ethical breeding of healthy, behaviorally sound dogs. The FDC’s goals include providing educational, social, and technical resources to breeders of both purebred and mixed breed dogs, helping us all learn more about how to breed good companions who are fit for sports or work. You can find out more at functionalbreeding.org or at the Functional Breeding facebook group, which is a friendly and inclusive community.
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Thursday Oct 08, 2020
Thursday Oct 08, 2020
Elinor Karlsson, Ph.D., is the director of the Vetebrate Genomics Group at the Broad Institute of MIT and Harvard and (incidentally) my boss. She has a deep knowledge about both population genetics and what we call "complex trait genomics," or the genetics of hard to pin down things like risk of developing cancer or a behavior problem. Elinor talked with me about a recent paper that looked for genetic variants associated with diseases in a large number of dogs from many breeds and mixes. She discusses what this paper found and some ways to intepret those findings. The paper is Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. https://journals.plos.org/plosgenetics/article?rev=2&id=10.1371/journal.pgen.1007361.
Elinor also discusses a paper about genetic testing that she published recently, and that paper is Moses, Lisa, Steve Niemi, and Elinor Karlsson. "Pet genomics medicine runs wild." (2018): 470-472 https://www.nature.com/articles/d41586-018-05771-0.
Find this episode's transcript here.
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